*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. The effect of the patch works for most users within 24 hours of application depending on the severity. However, results may vary from user to user. Therefore, EZP Incorporated in no way guarantees that 24 hour relief will be achieved in all users. Users should not subject the Prostaderm patch to direct heat. Most men experience relief within 24 hrs. We recommend wearing the patch 18-24 hours then remove it - for most men the relief can last weeks after one patch - for others it may take a second patch to experience weeks of relief.